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You are here:Home » Antibodies » Abs to Apoptosis, Caspase » Anti -Caspase 13 (CASP 13, CASP13, CASP-13, Evolutionarily Related Interleukin-1beta Converting Enzyme, ERICE)

Anti -Caspase 13 (CASP 13, CASP13, CASP-13, Evolutionarily Related Interleukin-1beta
Converting Enzyme, ERICE)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Purified B
Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death is finally caused by members of the caspase family of proteases and caspase activated DNases. A novel member in the caspase family was recently identified and designated ERICE (for Evolutionarily Related Interleukin-1 beta Converting Enzyme) and caspase-13 (1). Caspase-13 belongs to the ICE subfamily of caspases. Overexpression of caspase-13 induces apoptosis. Caspase-13 was activated by caspase-8, which is a key enzyme in death receptor induced apoptosis. Caspase-13 is expressed in a variety of human tissues and cell lines (1).
Catalog #C2089-01C
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 0.5-1ug/ml.
Optimal dilutions to be determined by the researcher.
Positive ControlHL60 cell lysate. ~43kD
Storage and StabilityMay be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.2, 0.2% sodium azide.
PurityPurified by ammonium sulfate precipitation.
ImmunogenSynthetic peptide corresponding to amino acids 91 to 105 of human caspase-13 (1).
SpecificityRecognizes human, mouse and rat Casp-13.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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