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You are here:Home » Antibodies » Abs to Apoptosis, Caspase » Anti -Caspase 14

Anti -Caspase 14

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B
Caspases are a family of cysteine proteases that are key mediators of programmed cell death or apoptosis. The precursor form of all caspases is composed of a prodomain, and large and small catalytic subunits. The active forms of caspases are generated by several stimuli including ligand-receptor interactions, growth factor deprivation and inhibitors of cellular functions. All known caspases require cleavage adjacent to aspartates to liberate one large and one small subunit, which associate into a2b2 tetramer to form the active enzyme. Caspase-14 is a newly identified member of Caspase family. It has conserved active site pentapeptide, QACRG. However, no proteolytic or biological activities have been identified so far. It's high expression in embryonic tissues and limited expression in adult tissues suggests that it may have some role during ontogenesis.
Catalog #C2089-10D
Positive Control mouse spleen
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG
Clone No8J518
HostMouse
SourceMouse
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.2, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenThis antibody was raised against a synthetic peptide corresponding to amino acids 2-18 of mouse Caspase-14.
SpecificityIn mouse spleen, a 30kD band is observed. Species Crossreactivity: Mouse
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesCASP-14, CASP14, EC=3.4.22, MGC119078, MGC119079, MICE, Mini ICE


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