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Specifications

Clone Host Grade Applications Polyclonal Rabbit Affinity Purified E B

b-catenin is an adherens junction protein. Adherens junctions (AJs; also called the zonula adherens) are critical for the establishment and maintenance of epithelial layers, such as those lining organ surfaces. AJs play a role in mediating the adhesion between cells, signaling the presence of neighboring cells, and anchoring the actin cytoskeleton. In serving these roles, AJs also regulate normal cell growth and behavior. At several stages of embryogenesis, wound healing, and tumor cell metastasis, cells form and leave epithelia. This process, which involves the disruption and reestablishment of epithelial cell-cell contacts, may be regulated by the disassembly and assembly of AJs.
Catalog #	C2096-60F
Applications	Suitable for use in ELISA and Western Blot. Other applications not tested.
Recommended Dilution	ELISA: 0.05-0.2ug/ml
	Western Blot: 0.5-2ug/ml
	Optimal dilutions to be determined by the researcher.
Storage and Stability	Lyophilized powder may be stored at -20°C. Reconstitute with sterile 40-50% glycerol, aliquot and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number	n/a
Clone Type	Polyclonal
Isotype	IgG
Host	Rabbit
Source	Human
Concentration	~0.5mg/ml
Form	Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide.
Purity	Purified by immunoaffinity chromatography.
Immunogen	Synthetic peptide within residues 700-750 of human b-Catenin protein (Swiss Prot: P35222).
Specificity	Recognizes endogenous levels of human b-catenin protein.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.