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You are here:Home » Antibodies » Abs to Catenin » Anti -Catenin beta, NT (CTNNB1, Catenin beta-1, Beta-catenin, CTNNB, OK/SW-cl.35, PRO2286)

Anti -Catenin beta, NT (CTNNB1, Catenin beta-1, Beta-catenin, CTNNB, OK/SW-cl.35, PRO2286)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
Beta catenin plays a central role in cell adhesion, bridging between cadherins and actin cytoskeleton. These activities are regulated through its differential interaction with several molecular partners, including cell- cell adherens junctions (AJ) molecules, components of its degradation complex, and transcription factors. Beta-catenin is composed of three domains: a central armadillo repeat domain and two N- and C-terminal tails. Beta-catenin can be phosphorylated by serine-threonine kinase, such as GSK-3. The phosphorylated beta-catenin will affect the protein association of beta-catenin to E-cadherin and alpha-cateinin that occurs in the cell. This process can be reversed by dephosphorylation of beta-catenin.
Catalog #C2096-60H
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:5000-1:20,000
Western Blot: 1:500-1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to human beta catenin.
SpecificityRecognizes human beta catenin. Species Crossreactivity: rat and mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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