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You are here:Home » Antibodies » Abs to Catenin » Anti -Catenin, beta, phosphorylated (Ser33/37/Thr41)

Anti -Catenin, beta, phosphorylated (Ser33/37/Thr41)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
Beta-catenin is a key downstream effector in the Wnt signaling pathway. It is implicated in two major biological processes of vertebrates: early embryonic de- velopment and tumorigenesis. CK1 phosphorylates b-catenin on Ser45. This phosphorylation event primes b-catenin for subsequent phosphorylation by GSK-3. GSK-3b destabilizes b-catenin by phosphorylating it at Ser33, 37 and Thr41. Mutations in these phosphorylation sites, which result in the stabilization of b-catenin protein levels, have been found in many tumor cell lines.
Catalog #C2096-61
ApplicationsSuitable for use in Western Blot.. Other applications have not been tested.
Recommended DilutionsWestern Blot: 1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot Determined
FormSupplied as liquid in 10mM HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol. No preservative added.
PurityPurified by Protein A affinity chromatography.
ImmunogenSynthetic phosphopeptide corresponding to residues surrounding Ser33, Ser37 and Thr41 of human beta-catenin. Species sequence homology: porcine, chicken, bovine, Xenopus, zebrafish and canine
SpecificityRecognizes endogenous levels of human beta-catenin only when phosphorylated at Ser33, Ser37 or Thr41. It does not recognize beta-catenin phosphorylated at other sites. Species Crossreactivity: rat, mouse and monkey.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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