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You are here:Home » Antibodies » Abs to Catenin » Anti -Catenin, beta, phosphorylated (Thr41/Ser45)

Anti -Catenin, beta, phosphorylated (Thr41/Ser45)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
Catalog #C2096-62
Beta-catenin is one of the key downstream effectors in the Wnt signaling pathway (1). It has been implicated in two major biological processes of vertebrates early embryonic development (2) and tumorigenesis (3). GSK-3beta or other kinases may destabilize beta-catenin by phosphorylating it at serines 33, 37, 45 and/or threonine 41 (4). Stabilizing mutations of these phosphorylation sites in beta-catenin have been found in many tumor cell lines (5).
ApplicationsSuitable for use in ELISA and Western Blot.. Other applications have not been tested.
Recommended DilutionWestern Blot: 1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as liquid in 10mM HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol. No preservative added.
PurityPurified by Protein A affinity chromatography.
ImmunogenSynthetic phosphopeptide (KLH coupled) corresponding to residues surrounding Thr41 and Ser45 of human beta-catenin.
SpecificityPhospho-beta-Catenin (Thr41/Ser45) Antibody detects endogenous levels of beta-catenin only when phosphorylated at Thr41 or Ser45. This antibody does not recognize beta-catenin phosphorylated at other sites.
Species CrossreactivityHuman, mouse and monkey
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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