You are here:Home
»
Antibodies
»
Abs to Catenin
»
Anti -CTNNB1 (Catenin beta-1, Beta-catenin, CTNNB, OK/SW-cl.35, PRO2286)
Anti -CTNNB1 (Catenin beta-1, Beta-catenin, CTNNB, OK/SW-cl.35, PRO2286)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
B IP IH IC FC |
|
| Beta-catenin is an adherens junction protein, which mediates cell-cell adhesion, cell-cell communication and contributes to cytoskeletal integrity. It is similar to the product of the Drosophila segment polarity gene armadillo. Like armadillo, beta-catenin is part of the E cadherin multiprotein complex that regulates pattern formation at several stages of embryogenesis. In addition beta-catenin is involved in wound healing and tumor cell metastasis. Beta-catenin is part of the Wnt signaling cascade. It interacts with Tcf and Lef to activate gene transcription and regulates cell growth. Beta-catenin accumulation has been observed in various cancers, especially in colorectal tumors and hepatoblastoma. Beta-catenin-mediated transcription is down regulated when the protein binds to the tumor suppressor protein APC. | | | Catalog # | C2096-64E | | Applications | Suitable for use in Flow Cytometry, Immunocytochemistry, Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Immunohistochemistry (Formalin fixed paraffin embedded): 10ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | EM-22 | | Host | Mouse | | Source | Human | | Concentration | As reported | | Form | Supplied as a liquid in PBS, 15mM sodium azide, pH 7.4. | | Purity | Purified by Protein A affinity chromatography. | | Immunogen | Recombinant corresponding to human beta-catenin. | | Specificity | Recognizes human beta-catenin. Species sequence homology: hamster and mouse. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
External Links
|
