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You are here:Home » Antibodies » Abs to Cathepsin » Anti -Cathepsin B (Cathepsin-B, CPSB, CTSB, Cathepsin B1, Amyloid Precursor Protein Secretase, APP Secretase, APPS, Preprocathepsin B, Procathepsin B)

Anti -Cathepsin B (Cathepsin-B, CPSB, CTSB, Cathepsin B1, Amyloid Precursor Protein
Secretase, APP Secretase, APPS, Preprocathepsin B, Procathepsin B)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Sheep Affinity Purified E
Cathepsin B is thought to play an increasingly important role in apoptosis and its release from the lysosome under cell stress leads to Bid cleavage, cytochrome C release and nuclear fragmentation. Cathepsin B is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete processing of APP is thought to be a causative factor in Alzheimer disease.
Catalog #C2097-03B
Overexpression of cathepsin B has been associated with oesophageal adenocarcinoma and other tumors, and has in particular been implicated in tumor invasion and metastasis.
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionELISA: 1:2,000-1:20,000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostSheep
SourceHuman
Concentration~5mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenNative, from placenta
SpecificityRecognizes human CATHEPSIN B.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesCysteine Protease


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