Login

Forgot your password?
New User?
Remember me
banner banner

You are here:Home » Antibodies » Abs to Cathepsin » Anti -Cathepsin K

Anti -Cathepsin K

Pricing

  For pricing information, USA customers sign in.
  Outside USA? Please contact your distributor for pricing.

Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B IH
Human cathepsin K (EC 3.4.22.38) is a member of the cysteine protease (papain) family with high primary sequence homology to cathepsins S, L, and B. It has been shown that cathepsin K plays a major role in the resorption of the bone matrix by osteoclasts. Cathepsin K has a potential as a drug target for the diseases related to bone matrix metabolism such as osteoporosis. Autoproteolytic processing of the N-terminal 99 amino acid propeptide produces the active, mature form of cathepsin K. It is presumed that the activation of procathepsin K in vivo occurs in the bone resorption pit, which has a low-pH environment. Humans lacking cathepsin K exhibit pycnodysostosis, which is characterized by short stature and osteosclerosis.
Catalog #C2097-69J
ApplicationsSuitable for use in Indirect ELISA, Immunohistochemistry and Western Blot. Other applications not tested.
Recommended DilutionsOptimal dilutions to be determined by the researcher.
Amino Acid SequenceMRGSHHHHHH GSLYPEEILD THWELWKKTH RKQYNNKVDE ISRRLIWEKN LKYISIHNLE ASLGVHTYEL AMNHLGDMTS EEVVQKMTGL KVPLSHSRSN DTLYIPEWEG RAPDSVDYRK KGYVTPVKNQ GQCGSCWAFS SVGALEGQLK KKTGKLLNLS PQNLVDCVSE NDGCGGGYMT NAFQYVQKNR GIDSEDAYPY VGQEESCMYN PTGKAAKCRG YREIPEGNEK ALKRAVARVG PVSVAIDASL TSFQFYSKGV YYDESCNSDN LNHAVLAVGY GIQKGNKHWI IKNSWGENWG NKGYILMARN KNNACGIANL ASFPKM
Storage and StabilltyLyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG2b
Clone No10C464
HostMouse
SourceHuman
Concentration~1mg/ml (after reconstitution)
FormSupplied as a lyophilized powder in PBS, pH 7.2. No preservative added. Reconstitute with 100ul sterile ddH2O.
PurityPurified by Protein G affinity chromatography
ImmunogenRecombinant protein corresponding to 224aa from human Cathepsin K expressed in E. coli
SpecificityRecognizes human Cathepsin K.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


External Links