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You are here:Home » Antibodies » Abs to Cathepsin » Anti -Cathepsin L (Cathepsin L heavy chain, Cathepsin L light chain, CATL, CTSL, Major excreted protein, MEP)

Anti -Cathepsin L (Cathepsin L heavy chain, Cathepsin L light chain, CATL, CTSL, Major
excreted protein, MEP)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Ascites E B IH
Cathepsins are lysosomal proteases that play an important role in the intracellular degradation of exogenous and endogenous proteins, activation of enzyme precursors, and tumor invasion and metastasis. Normally located in lysosomes of almost all mammalian cells, they can be secreted from the cell under certain conditions. Cathepsin L is responsible for most of the intralysosomal breakdown of normal cells. Cathepsin L is secreted by numerous transformed cells in its inactive proform, and mRNA expression level seems to correlate with their metastatic potential.
Catalog #C2097-70J
ApplicationsSuitable for use in ELISA, Western Blot, Immunohistochemistry and Functional Studies. Other applications not tested.
Recommended DilutionELISA: 1:200
Immunohistochemistry: frozen sections
Functional Studies: Suppresses the growth of malignant myeloma cells.
Optimal dilutions to be determined by the researcher.
Positive Control Whole cell extract from cultured mink lung cell line.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No8J540
HostMouse
SourceHuman
Concentration~5mg/ml
FormSupplied as a liquid, 15mM sodium azide.
PurityAscites
ImmunogenPurified full length native protein (Human lung cancer line EPLC 32 M1). Epitope
SpecificityRecognizes native and denatured forms of human cathepsin L (25kD) and procathepsin L (42kD). Does not react with human cathepsin types B, D, H and S, procathepsins B and D, and procathepsin H, rat cathepsin B, and mouse procathepsins B and D. Species Crossreactivity: mouse procathepsin L (weak), rat cathepsin L (strong), and mink cathepsin and procathepsin L.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesCathepsin L heavy chain, Cathepsin L light chain, CATL, CTSL, Major excreted protein, MEP


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