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Specifications

Clone Host Grade Applications Monoclonal Mouse Affinity Purified B IH

Cathepsins are localized primarily in lysosomes or endosomes, but translocated to the cytosol during apoptosis. The translocation allows these proteases to interact with caspases or other apoptosis signaling mechanisms. Studies show that cathepsins cleave certain caspases, and caspase inhibitors can inhibit cathepsin activity in vitro.
Catalog #	C2097-74A
Applications	Suitable for use in Immunohistochemistry and Western Blot. Other applications not tested.
Recommended Dilutions	Immunohistochemistry: Paraffin sections after microwave treatment.
	Optimal dilutions to be determined by the researcher.
Storage and Stability
	May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number	n/a
Clone Type	Monoclonal
Isotype	IgG1
Clone No	6D232
Host	Mouse
Source	Human
Concentration	1mg/ml
Form	Supplied as a liquid in PBS containing 0.01% thimerosal.
Purity	Purified by Protein G affinity chromatography.
Immunogen	Synthetic peptide corresponding to aa 200-217 (Y200SVANDTGFVDIPKQEKA217) of human procathepsin L.
Specificity	Recognizes the epitope I211PKQ214 of human procathepsin L. Recognizes mature human single or two chain cathepsin L (heavy chain) and human procathepsin L. Does not cross react with mature cathepsins B, D, H, K, S and procathepsins B, D, F, S, W.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.