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You are here:Home » Antibodies » Antibodies-Ion Channel » Anti -Cav1.3 (Voltage-dependent L-type calcium channel subunit alpha-1D, Voltage-gated calcium channel subunit alpha Cav1.3, Cacna1d, Calcium channel L type alpha-1 polypeptide isoform 2)

Anti -Cav1.3 (Voltage-dependent L-type calcium channel subunit alpha-1D, Voltage-gated
calcium channel subunit alpha Cav1.3, Cacna1d, Calcium channel L type alpha-1 polypeptide
isoform 2)


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Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IP IH IC
Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological
cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligand-gated, other gating systems and finally those that are classified differently, having more exotic characteristics.
Catalog #C2097-85B5
The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels.
Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2). Specifically, Cav1.3, also known as the calcium channel, voltage-dependent, L type, alpha 1D subunit (CACNA1D), is a human gene. Cav1.3 subunits are primarily expressed in neurons and neuroendocine cells. Some studies suggest however that Cav1.3 is also found in the atria, and may figure prominently in atrial arrhythmias (3).Cav1.3 also carries the primary sensory receptors of the mammalian cochlea, and are also expressed in the electromotile outer hair cells (4).
ApplicationsSuitable for use in Immunofluorescence, Western Blot, Immunoprecipitation, Immunohistochemistry and Immunocytochemistry. Other applications not tested.
Recommended DilutionImmunofluorescence: 1-10ug/ml
Western Blot: 1-10ug/ml. If results are poor, use lysate without boiling. Heat at 37°C for 15min
Immunohistochemistry: 0.1-1ug/ml
Immunocytochemistry: 0.1-1ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
Clone No10F688
FormSupplied as a liquid in PBS, pH 7.4, 0.09% sodium azide, 50% glycerol.
PurityPurified by Protein G affinity chromatography.
ImmunogenFusion protein aa 859-875 (N-Terminal) of rat Cav1.3 (also known as voltage dependent L-type calcium channel subunit alpha-1D, RAT
brain class D and RBD, accession number P27732).
SpecificityRecognizes rat Cav1.3. Species Crossreactivity: human and mouse
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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