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You are here:Home » Antibodies » Abs to Ion Channel » Anti -Calcium channel, voltage-dependent, beta 1 subunit (CAB1, CACNB1, Voltage-dependent L-type calcium channel subunit beta-1)

Anti -Calcium channel, voltage-dependent, beta 1 subunit (CAB1, CACNB1, Voltage-dependent
L-type calcium channel subunit beta-1)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IP IH IF
Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligand-gated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Calcium channel, voltage-dependent, beta 1 subunit, also known as CACNB1, is a human gene. The protein encoded by this gene belongs to the calcium channel beta subunit family. It plays an important role in the calcium channel by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.
Applications:
Suitable for use in Western Blot, Immunoprecipitation, Immunofluorescence and Immunohistochemistry. Other applications not tested.
Catalog #C2097-91S
Recommended DilutionsWestern Blot (Colormetric): 1ug/ml detects CavB1 in 10ug of rat brain lysate using IgG (HRP) goat x mouse as secondary. If results are poor, use lysate without boiling, heat at 37ºC for 15 minutes.
Immunohistochemistry: 0.1-1ug/ml
Immunofluorescence: 1-10ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2a
Clone No10F691
HostMouse
SourceRat
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.09% sodium azide, 50% glycerol.
PurityPurified by Protein G affinity chromatography.
ImmunogenSynthetic peptide corresponding to aa19-34 of rat CACNB1 (NP_059042).
SpecificityRecognizes rat CACNB1 at ~80, 55kD. Species Crossreactivity: human and mouse. Does not crossreact with CavB4.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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