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You are here:Home » Antibodies » Abs to Membrane Proteins » Anti -Caveolin 1 (Caveolin-1, CAV 1, CAV1, CAV, BSCL3, CGL3, MSTP085, VIP21)

Anti -Caveolin 1 (Caveolin-1, CAV 1, CAV1, CAV, BSCL3, CGL3, MSTP085, VIP21)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified IH
Official Symbol- CAV1. GenBank Accession Number(s)- NP_001744.2. GeneID- 857 (Human). Caveolins are a family of integral membrane proteins which are the principal components of caveolae membranes. Cavoleae are flask-shaped plasma membrane invaginations whose exact cellular function is not yet clear. Caveolins may act as scaffolding proteins within caveolar membranes by compartmentalizing and concentrating signaling molecules. Various classes of signaling molecules, including G-protein subunits, receptor and non-receptor tyrosine kinases, endothelial nitric oxide synthase (eNOS), and small GTPases, bind Cav-1 through its 'caveolin-scaffolding domain'. Currently, three different forms of caveolins are known: caveolin-1 (or VIP21), caveolin-2 and caveolin-3 (or M-caveolin). Caveolins are proteins of about 20 Kd, they form high molecular mass homo-oligomers. Structurally they seem to have N-terminal and C-terminal hydrophilic segments and a long central transmembrane domain that probably forms a hairpin in the membrane. Both extremities are known to face the cytoplasm. Caveolae are enriched with cholesterol and Cav-1 is one of the few proteins that binds cholesterol tightly and specifically.
Catalog #C2097-93M
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (paraffin): 17ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlHuman respiratory epithelium, bronchial smooth muscle, and alveoli
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.7, 0.1% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to the N-terminal region of human CAV-1.
SpecificityRecognizes human CAV-1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesCaveolin 1, Caveolae Protein, 22kDa


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