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You are here:Home » Antibodies » Abs to Chromatin Proteins » Anti -CBX4 (Chromobox Homolog 4, HPC2, NBP16, PC2)

Anti -CBX4 (Chromobox Homolog 4, HPC2, NBP16, PC2)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B IH IF
CBX4 is the human homolog of the Drosophila ‘Polycomb’ (Pc) protein which has been identified as a gene family member associated with a cellular memory system that is responsible for hte inheritance of gene activity by progeny cells. The human Pc homolog gene is more closely related to a Xenopus Pc homolog (XPc) that to a previously described human Pc homolog, CBX2 (hPc1). However, the hPc2 and CBX2/hPc1 proteins are shown to colocalize in interphase nuclei of human U-2 OS osteosarcoma cells, suggesting that the proteins are part of a common protein complex. The human protein is believed to function as a repressor of proto-oncogene activity and that interference with hPc2 function can lead to derepression of proto-oncogene transcription and subsequently to cellular transformation. Other reports describe PC2 as a protein that has SUMO E3 activity for the corepressors CtBP and CtBP2.
Catalog #C2098-79
ApplicationsSuitable for use in Immunohistochemistry, Western Blot, Immunofluorescence and ELISA. Other applications not tested.
Recommended DilutionImmunohistochemistry (paraffin): 2.5ug/ml
Western Blot: 1:1000-1:40,000
Immunofluorescence: 1:100-1:400
ELISA: 1:10,000-1:40,000
Optimal Dilutions to be determined by researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 0.01% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide, KLH-conjugated. Epitope: aa95-107 of human PC2 protein.
SpecificityRecognizes human Chromobox Homolog 4 (Drosophila Pc Class) (CBX4). Species Crossreactivity: mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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