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You are here:Home » Antibodies » Abs to Chromatin Proteins » Anti -CBX4, NT (E3 SUMO-protein Ligase CBX4, Chromobox Protein Homolog 4, Polycomb 2 Homolog, Pc2, hPc2)

Anti -CBX4, NT (E3 SUMO-protein Ligase CBX4, Chromobox Protein Homolog 4, Polycomb 2
Homolog, Pc2, hPc2)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B IH
CBX4 is a member of Drosophila Polycomb group gene family. The polycomb group (PcG) genes are essential for maintenance of proper expression patterns of developmental master regulators; changes in expression pf PcG proteins have been associated with cancer. CBX4 is a part of the cellular memory system responsible for the inheritance of gene activity by progeny cells. It participates in maintaining the transcriptionally repressive state of genes. CBX4 is part of acomplex that acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. CBX4 is an E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I.
Catalog #C2098-79B
ApplicationsSuitable for use in ELISA, Immunohistochemistry and Western Blot. Other applications not tested.
Recommended DilutionsImmunohistochemistry (FFPE): 1:50-1:100
Western Blot: 1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs Reported
FormSupplied as a liquid in PBS, 0.09% sodium azide.
PuritySupplied as a liquid in PBS, 0.09% sodium azide.
ImmunogenKLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 80-110 in the N-terminal region of human CBX4, UniProt Accession #O00257.
SpecificityRecognizes human CBX4. Species Crossreactivity: mouse
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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