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You are here:Home » Antibodies » Abs to G Proteins » Anti -CCR5 (Chemokine Receptor 5, CC-CCR-5, CD195)

Anti -CCR5 (Chemokine Receptor 5, CC-CCR-5, CD195)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E IH
The CC chemokine receptor 5 (CCR5) is a member of the CC chemokine receptor family. It has the characteristic structure of a 7 transmembrane G protein-coupled receptor (GPCR). CCR5 is a receptor for a number of inflammatory CC chemokines including MIP-1-alpha, MIP-1-beta and RANTES. It transduces a signal by increasing the intracellular calcium ion level and may play a role in the control of granulocytic lineage proliferation or differentiation. It also acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates. CCR5 is highly expressed in spleen, thymus, and also in the myeloid cell line THP-1, the promyeloblastic cell line KG-1A and on the CD4+ and CD8+ T-cells. Moreover, recent studies have highlighted the role of CCR5 in a variety of human diseases, ranging from infectious and inflammatory diseases to cancer.
Catalog #C2099-69H
ApplicationsSuitable for use in ELISA and Immunohistochemistry. Other applications not tested.
Recommended DilutionELISA: 0.05-2ug/ml
Immunohistochemistry (Paraffin): 5-10ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a lyophilized powder from PBS, pH 7.4, 0.02% sodium azide. Reconstitute with 80ul sterile ddH2O.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to the extracellular domain of human CCR5 (KLH).
SpecificityRecognizes human CCR5 protein.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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