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You are here:Home » Antibodies » Abs to G Proteins » Anti -CCR6 (Chemokine Receptor 6, CC-CCR-6)

Anti -CCR6 (Chemokine Receptor 6, CC-CCR-6)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E IH IC FC
CCR6 is a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein coupled receptors. It is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP 3 alpha). This receptor has been shown to be important for B lineage maturation and antigen driven B cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. CCR6 has been reported to be expressed in intestine, colon, liver, lymph node, spleen, lung, blood, umbilical cord, placenta, skin, and pancreas. It has also been reported to be expressed in lymphocytes, T cells, and B cells.
Catalog #C2099-70G
ApplicationsSuitable for use in ELISA, Flow Cytometry, Immunocytochemistry and Immunohistochemistry. Other applications not tested.
Recommended DilutionsELISA: 1:75,000
Flow Cytometry: 50-100ul, 1-3ul per 10e6 cells
Immunocytochemistry: 1:300
Immunohistochemistry (Paraffin): 1:250
Optimal dilutions to be determined by researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 1mg/ml BSA, 0.1% sodium azide.
PurityPurified by immunoaffinity chromatography
ImmunogenSynthetic peptide corresponding to aa18-46, Y18FVSVNTSYYSVDSEMLLCSLQEVRQFSR46, of human CCR6.
SpecificityRecognizes human CCR6. Peptide sequence is <50% identical to other human chemokine receptors in this region. Species Crossreactivity: mouse
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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