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You are here:Home » Antibodies » Abs to G Proteins » Anti -CCR1 (C-C Chemokine Receptor Type 1, C-C CKR-1, CC-CKR-1, CCR-1, Macrophage Inflammatory Protein 1-alpha Receptor, MIP-1alpha-R, RANTES-R, CD191, Cmkbr1)

Anti -CCR1 (C-C Chemokine Receptor Type 1, C-C CKR-1, CC-CKR-1, CCR-1, Macrophage
Inflammatory Protein 1-alpha Receptor, MIP-1alpha-R, RANTES-R, CD191, Cmkbr1)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Rat Affinity Purified B FC
CCR1 is a 43kD member of the GPCR #1 family of transmembrane proteins. Mouse CCR1 is expressed on osteoclasts, IL-13+ T cells, neutrophils, bone marrow-derived mast cells, eosinophils, monocytes and vascular intimal smooth muscle cells. Multiple chemokines are reported to bind to CCR1. MIP-1a/CCL3 and RANTES/CCL5 are natural ligands, while CCL15, CCL9 and CCL23 are potent angonists after N-terminal processing. Mouse CCR1 is a 7-transmembrane protein that is 355aa in length. It contains a 34aa N-terminal extracellular domain plus a 50aa C-terminal cytoplasmic tail. Over aa sequences 1-34, 92-107, 172-192 and 265-281 collectively, mouse CCR1 shares 76% and 89% aa identity with human and rat CCR1.
Catalog #C2099-76C
ApplicationsSuitable for use in Flow Cytometry and Western Blot. Other applications not tested.
Recommended DilutionFlow Cytometry: 2.5ug labels 10e6 cells
Western Blot: 2ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG2B
Clone No12K18
HostRat
SourceMouse
Concentration~0.5mg/ml after reconstitution
FormSupplied as a lyophilized powder in PBS, trehalose. Reconstitute with sterile PBS to 0.5mg/ml.
PurityPurified by Protein A/G affinity chromatography.
ImmunogenRecombinant corresponding to aa1-34, aa92-107, aa172-192, aa265-281 from mouse CCR1 expressed in E.coli.
SpecificityRecognizes mouse CCR1. Does not react with recombinant mouse CCR4, 5, or 8 is observed.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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