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You are here:Home » Antibodies » Abs to G Proteins » Anti -CCR1 (Chemokine Receptor 1, CC-CKR-1, CC-CCR-11)

Anti -CCR1 (Chemokine Receptor 1, CC-CKR-1, CC-CCR-11)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E
Chemokines play important roles in inflammation and critical for the recruitment of effector immune cells to sites of infection. Chemokines activate leukocytes by binding to G protein coupled receptors. The ever-growing chemokine receptor subtypes can be divided into 2 major groups, CXCR and CCR, based on the 2 major classes of chemokines. One of the CCR receptors, CCR1, is expressed on neutrophils, monocytes, lymphocytes, and eosinophils and binds the leukocyte chemoattractant and hemopoiesis regulator macrophage-inflammatory protein (MIP-1 ), eotaxin, as well as several other related chemokines. Mice lacking the chemokine receptor CCR1 have defects in neutrophil trafficking and proliferation.
Catalog #C2099-90C
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
HybridomaSp2/0-Ag14 myeloma cells with spleen cells from Balb/c mice.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1, k
Clone No10g166
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a lyophilized powder in 0.01M PBS, pH 7.0. Reconstitute with sterile ddH2O to 1mg/ml.
PurityPurified by Protein G affinity chromatography.
Immunogen15 amino-acid peptide corresponding to the amino acid sequence 305-319 of human CCR1.
SpecificityRecognizes the above peptide conjugated KLH in EIA. Species crossreactivity: Does not cross react with KLH, BSA and HSA.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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