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You are here:Home » Antibodies » Abs to G Proteins » Anti -CCR2 (Chemokine receptor 2, CC-CCR-2, CKR2)

Anti -CCR2 (Chemokine receptor 2, CC-CCR-2, CKR2)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Purified E
ELISA positive samples that are still undergoing R&D testing. Available testing data will be listed under the Applications section. Often times, multiple samples will be included, differing in the amino acid sequence used to raise the immune sera.
Catalog #C2099-91A
Chemokines play important roles in inflammation and critical for the recruitment of effector immune cells to sites of infection. Chemokines activate leukocytes by binding to G protein coupled receptors (1). The ever-growing chemokine receptor subtypes can be divided into 2 major groups, CXCR and CCR, based on the 2 major classes of chemokines. One of the CCR receptors, CCR1, is expressed on neutrophils, monocytes, lymphocytes, and eosinophils and binds the leukocyte chemoattractant and hemopoiesis regulator macrophage-inflammatory protein (MIP-1 ), eotaxin, as well as several other related chemokines (2-4). Mice lacking the chemokine receptor CCR1 have defects in neutrophil trafficking and proliferation (5,6).
ApplicationsSuitable for use in ELISA. Other applications have not been tested.
Recommended DilutionELISA: 1:100-1:1000
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in glycerol, 0.1% sodium azide.
PurityPurified
ImmunogenSynthetic peptide corresponding to amino acids 352-366 of human CCR2.
SpecificityRecognizes Human CCR2.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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