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You are here:Home » Antibodies » Abs to G Proteins » Anti -CCR2, NT (Chemokine Receptor 2, CC-CCR-2, CKR2)

Anti -CCR2, NT (Chemokine Receptor 2, CC-CCR-2, CKR2)

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Specifications

Clone Host Grade Applications
Monoclonal Rabbit Supernatant IP IH IC FC
CCR2, C-C chemokine receptor type 2, is a G protein-coupled, seven-transmembrane domain receptor protein. It has been found to be a monocyte chemoattractant protein 1(MCP-1)-specific receptor (1,2). Activation of the CCR2b isoform by MCP-1 binding has been shown to trigger intracelluluar Ca2+ flux and activation of the Jak/Stat pathway (3). A variety of chemokine receptors, including CCR2, can serve as HIV fusion co-factors (4), making elucidating their specific functions important for more fully describing the process of HIV infection.
Catalog #C2099-91C
ApplicationsSuitable for use in Flow Cytometry, Immunoprecipitation, Immunohistochemistry and Immunocytochemistry. Other applications not tested.
Recommended DilutionFlow Cytometry: 1:25
Immunohistochemistry: 1:100
Immunocytochemistry: 1:100
Immunoprecipitation: 1:50
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Manufactured incorporating RabMAb® technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Clone TypeMonoclonal
IsotypeIgG
Clone No6k96
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in 50mM Tris-Glycine, pH 7.4, 0.15M sodium chloride, 0.01% sodium azide, 0.05% BSA, 40% glycerol.
PuritySupernatant
ImmunogenA synthetic peptide cooresponding to the N-terminal residues of the human C-C chemokine receptor type 2 .MW: 42-52kD.
SpecificityRecognizes human Chemokine Receptor 2. Species Crossreactivity: mouse. Does not crossreact with other CKR family members.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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