Anti -CCR3 (CD193, CC Chemokine Receptor Type 3, CC CKR 3, CC CKR3, B Chemokine Receptor,
CMKBR3, Eosinophil CC Chemokine Receptor 3, Eosinophil Eotaxin Receptor, MGC102841)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
IH |
|
| CCR3, a Chemokine Receptor, was cloned from human eosinophils (Daugherty et al., 1996). This receptor binds specifically the chemokine eotaxin and activates eosinophil leukocytes. CCR3 also responds to a variety of beta-chemokines (CC motif) including RANTES, monocyte chemotactic proteins, and mucosae-associated epithelial chemokine (MEC). CCR3 is a key mediator of allergic reactions; activation of this receptor stimulates the production of interleukins required for activation of basophils and eosinophils (Sallusto et al., 1997). CCR3 plays a role in the progression and pathogenesis of inflammatory diseases such as asthma, multiple sclerosis, and Alzheimer's disease. This receptor also facilitates HIV-1 penetration in heart and brain. | | | Catalog # | C2099-92V | | Applications | Suitable for use in Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Immunohistochemistry (paraffin): 10ug/ml | | Optimal dilutions to be determined by the researcher. | | Positive Control | Human tonsil, lymphocytes | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | As reported | | Form | Supplied as a liquid in PBS, 0.1% sodium azide. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide corresponding to the 3rd extracellular domain of human CCR3 (KLH). | | Specificity | Recognizes human CCR3. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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