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You are here:Home » Antibodies » Abs to G Protein Receptors » Anti -CCR3 (CD193, CC Chemokine Receptor Type 3, CC CKR 3, CC CKR3, B Chemokine Receptor, CMKBR3, Eosinophil CC Chemokine Receptor 3, Eosinophil Eotaxin Receptor, MGC102841)

Anti -CCR3 (CD193, CC Chemokine Receptor Type 3, CC CKR 3, CC CKR3, B Chemokine Receptor,
CMKBR3, Eosinophil CC Chemokine Receptor 3, Eosinophil Eotaxin Receptor, MGC102841)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified IH
CCR3, a Chemokine Receptor, was cloned from Human eosinophils (Daugherty et al., 1996). This receptor binds specifically the chemokine eotaxin and activates eosinophil leukocytes. CCR3 also responds to a variety of beta-chemokines (CC motif) including RANTES, monocyte chemotactic proteins, and mucosae-associated epithelial chemokine (MEC). CCR3 is a key mediator of allergic reactions; activation of this receptor stimulates the production of interleukins required for activation of basophils and eosinophils (Sallusto et al., 1997). CCR3 plays a role in the progression and pathogenesis of inflammatory diseases such as asthma, multiple sclerosis, and Alzheimer's disease. This receptor also facilitates HIV-1 penetration in heart and brain. CCR3 has been reported in blood, brain, lung, bone marrow, kidney, liver, lymph node, placenta, skin, spleen, thymus, thyroid, uterus, and vessel. Within these tissues, CCR3 is expressed in specific cell types, including eosinophils, basophils, Th2 cells, and mast cells.
Catalog #C2099-92Y
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (paraffin): 8ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlHuman nasal mucosa, allergic rhinitis
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.7, 0.1% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to the C-terminal domain of human CCR3.
SpecificityRecognizes human CCR3.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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