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You are here:Home » Antibodies » Abs to G Proteins » Anti -CCR4 (CC chemokine receptor type 4, CCCKR4, CCR4, ChemR13, CKR4, CMKBR4, HGCN 14099, K5 5, MGC88293)

Anti -CCR4 (CC chemokine receptor type 4, CCCKR4, CCR4, ChemR13, CKR4, CMKBR4, HGCN 14099,
K5 5, MGC88293)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E B IH IC FC
Chemokine receptors are specialized proteins that function at the surface of cells, and enable chemokines to trigger internal cellular processes. Chemokines and their receptors play a pivotal role in lymphocyte trafficking, recruiting and recirculation. Chemokines act through seven transmembrane G protein-coupled receptors. The chemokine system is increasingly recognized to play an important role in lymphocyte biology.
Catalog #C2099-93A
CCR4 is a chemokine receptor and is preferentially expressed on type 2 helper T (Th2-type) cells. In contrast to other chemokine receptors, the expression of CCR4 and CCR8 on Th2 cells is transiently increased following TCR and CD28 engagement. Moreover, activated Th1 cells up-regulate CCR4 expression and functional responsiveness to thymus- and activation-regulated chemokine. ApplicationsSuitable for use in ELISA, Western Blot, Flow Cytometry, Immunocytochemistry and Immunohistochemistry. Other applications have not been tested.
Recommended DilutionELISA: 1:30,000
Western Blot: 1:500
Immunocytochemistry: 1:200 (acetone fixation)
Immunohistochemistry (paraffin): 1:100
Flow Cytometry: 1:12
Optimal dilutions to be determined by researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostGoat
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.2, with 1 mg/ml BSA and 0.1% sodium azide.
PurityPurified by immunoaffinity chromatography.
Immunogen23 amino acid synthetic peptide SNYYLYESIPKPCTKEGIKAFGE.
SpecificityPeptide sequence is <50% identical to other Chemokine receptors in this region. Crossreacts with human.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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