Anti -CCR4 (CC chemokine receptor type 4, CCCKR4, CCR4, ChemR13, CKR4, CMKBR4, HGCN 14099,
K5 5, MGC88293)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Goat |
Affinity Purified |
E B IH IC FC |
|
| Chemokine receptors are specialized proteins that function at the surface of cells, and enable chemokines to trigger internal cellular processes. Chemokines and their receptors play a pivotal role in lymphocyte trafficking, recruiting and recirculation. Chemokines act through seven transmembrane G protein-coupled receptors. The chemokine system is increasingly recognized to play an important role in lymphocyte biology. | | | Catalog # | C2099-93A | | CCR4 is a chemokine receptor and is preferentially expressed on type 2 helper T (Th2-type) cells. In contrast to other chemokine receptors, the expression of CCR4 and CCR8 on Th2 cells is transiently increased following TCR and CD28 engagement. Moreover, activated Th1 cells up-regulate CCR4 expression and functional responsiveness to thymus- and activation-regulated chemokine. Applications | Suitable for use in ELISA, Western Blot, Flow Cytometry, Immunocytochemistry and Immunohistochemistry. Other applications have not been tested. | | Recommended Dilution | ELISA: 1:30,000 | | Western Blot: 1:500 | | Immunocytochemistry: 1:200 (acetone fixation) | | Immunohistochemistry (paraffin): 1:100 | | Flow Cytometry: 1:12 | | Optimal dilutions to be determined by researcher. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Polyclonal | | Host | Goat | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in PBS, pH 7.2, with 1 mg/ml BSA and 0.1% sodium azide. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | 23 amino acid synthetic peptide SNYYLYESIPKPCTKEGIKAFGE. | | Specificity | Peptide sequence is <50% identical to other Chemokine receptors in this region. Crossreacts with human. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
External Links
|
