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You are here:Home » Antibodies » Abs to G Proteins » Anti -CCR5, CT (Chemokine Receptor 5, CC-CKR-5, CD195)

Anti -CCR5, CT (Chemokine Receptor 5, CC-CKR-5, CD195)

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Specifications

Clone Host Grade Applications
Monoclonal Rabbit Supernatant B FC
CKR5, or C-C chemokine receptor type 5, is a G protein-coupled, seven-transmembrane domain receptor protein. It has been found to be the receptor for MIP-1-alpha, MIP-1-beta and RANTES (1,2), and functions to transduce a signal by increasing the intracellular calcium ions level. Entry of HIV-1 into target cells requires cell-surface CD4 and additional host cell cofactors. It has been determined that CKR5 serves as the principal cofactor for entry of primary macrophage-tropic strains of HIV-1 into cells (3).
Catalog #C2099-97H
ApplicationsSuitable for use in Flow Cytometry and Western Blot. Other applications not tested.
Recommended DilutionFlow Cytometry: 1:20
Western Blot 1:1000 -1:10,000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Manufactured incorporating RabMAb® technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Clone TypeMonoclonal
IsotypeIgG
Clone No6k98
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in 50mM Tris- Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
PuritySupernatant
ImmunogenSynthetic peptide corresponding to residues in C-terminus (cytoplasmic domain) of human CCR5.
SpecificityRecognizes human and mouse CCR5. Does not cross-react with other G-protein coupled receptor 1 family members.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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