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You are here:Home » Antibodies » Abs to G Proteins » Anti -CCR8 (TER1, CKR-L1, ChemR1, Chemokine Receptor 8, CC-CKR-8)

Anti -CCR8 (TER1, CKR-L1, ChemR1, Chemokine Receptor 8, CC-CKR-8)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
CCR8 is one of the chemokine receptors that are required as coreceptors for HIV infection. The genes encoding human and murine CCR8 were cloned and designated TER1, CKR-L1, and ChemR1 (1-4). The encoded seven transmembrane protein was identified as the receptor for human CC chemokine I-309 and renamed CCR8. Recently, CCR8 was found to serve as a coreceptor for diverse T-cell tropic, dual-tropic and macrophage-tropic HIV-1 strains (5). CCR8 mediates CC chemokine I-309 induced monocyte chemoattraction and HIV-1 envelope fusion and virus infection, which can be prevented by the CCR8 ligand I-309. CCR8 is expressed in spleen, thymus and T lymphoblastic cell lines.
Catalog #C2100
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:500-1:1,000
Optimal dilutions to be determined by the researcher.
Positive ControlHuman spleen tissue lysate
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C or colder. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration0.5mg/ml
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenPeptide corresponding to amino acids 183 to 201 of human CCR8, which locate in the second extracellular loop (1-3).
SpecificityRecognizes human CCR8 (TER1, CKR-L1, ChemR1, Chemokine Receptor 8, CC-CKR-8). A ~50kD band can be detected.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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