Anti -CCR10 (C-C Chemokine Receptor Type 10, Chemokine (C-C Motif) Receptor 10, C-C
CKR-10, CC-CKR-10, CCR-10, G-protein Coupled Receptor 2, GPR2)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
IH |
|
| GPR2/CCR10, a Chemokine Receptor, encodes a protein that most closely resembles the interleukin-8 receptor. The keratinocyte-produced chemokine CCL27 activates CCR10 and is involved in T cell-mediated skin inflammation. GRP2/CCR10 has been reported to be ubiquitously expressed. Transcripts for this receptor have been identified in peripheral tissues including adult small intestine and fetal liver, testis, placenta, and skin. In the skin, this receptor is constitutively expressed in melanocytes, fibroblasts, and microvascular endothelial cells. It is also detected in T cells, Langerhans cells, and peripheral blood mononuclear cells but not in keratinocytes (Homey et al., 2000), dendritic cells, or in various brain regions (Marchese et al., 1994). ESTs have been isolated from brain, eye, and kidney libraries. | | | Catalog # | C2100-15B | | Applications | Suitable for use in Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Immunohistochemistry (paraffin): 11-44ug/ml | | Optimal dilutions to be determined by the researcher. | | Positive Control | Human Thymus | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in PBS, pH 7.7, 0.1% sodium azide. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide corresponding to the 2nd extracellular domain of human G Protein-Coupled Receptor CCR10. | | Specificity | Recognizes human CCR10. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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