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You are here:Home » Antibodies » Abs to G Protein Receptors » Anti -CCR1 (Chemokine Receptor 1, CC-CCR-1) (PE)

Anti -CCR1 (Chemokine Receptor 1, CC-CCR-1) (PE)

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Specifications

Clone Host Grade Applications
Monoclonal Rat Affinity Purified FC
CCR1 (C-C chemokine receptor 1; also known as MIP-1a receptor and CD191) is a 43kD member of the G protein-coupled receptor 1 family of transmembrane proteins. Mouse CCR1 is expressed on osteoclasts, IL-13+ T cells, neutrophils, bone marrow-derived mast cells, eosinophils, monocytes, and vascular intimal smooth muscle cells. Multiple chemokines are reported to bind to CCR1. MIP-1a /CCL3 and RANTES/CCL5 are natural ligands, while CCL15, CCL9 and CCL23 are potent agonists after N-terminal processing. Mouse CCR1 is a seven transmembrane protein that is 355aa in length. It contains a 34aa N-terminal extracellular domain plus a 50aa C-terminal cytoplasmic tail. Over aa sequences 1-34, 92-107, 172-192 and 265-281 collectively, mouse CCR1 shares 76% and 89% aa identity with human and rat CCRI respectively.
Catalog #C2100-16E
ApplicationsSuitable for use Flow Cytometry. Other applications not tested.
Recommended DilutionFlow Cytometry: 10ul per 10e6 cells
Optimal dilutions to be determined by the researcher.
HybridomaMyeloma cells with B cells from Balb/c mice.
Storage and StabilityMay be stored at 4°C before opening. DO NOT FREEZE! Stable at 4°C as an undiluted liquid. Dilute only prior to immediate use. Stable for at least 12 months at 4°C. Freezing R-Phycoerythrin (PE) conjugates will result in a substantial loss of activity. PE conjugates are sensitive to light.
Clone TypeMonoclonal
IsotypeIgG2b
Clone No11D87
HostRat
SourceMouse
Concentration~0.025mg/ml
FormSupplied as a liquid in PBS, up to 0.5% BSA , 0.1% sodium azide. Labeled with R-Phycoerythrin (PE).
PurityPurified by Protein G affinity chromatography.
ImmunogenE. coli-derived recombinant mouse CCR1. Extracellular regions (aa1-34, aa92-107, aa172-192, aa 65-281); UniProt Accession Number P51675
SpecificityRecognizes mouse CCR1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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