CCR11 is a G protein-coupled, seven-transmembrane receptor protein that plays a role in the chemotaxis and trafficking of leukocytes. Showing similar binding affinities as does CCR2 and CCR10, CCR11 has been shown to specifically bind the MCP- (monocyte chemoattractant protein) family of chemokines, including MCP-4, MCP-2, and MCP-1. It was also shown to bind eotaxin. Though CCR11 shares functional similarity to CCR2 because it recognizes members of the MCP family, CCR11 has a distinct expression pattern.

Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.

ELISA: 1:37,500 Western Blot: 1:500 Immunohistochemistry (Paraffin): 1:125 Optimal dilution determined by the researcher.

May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Synthetic peptide corresponding to aa4-31, EQNQSTDYYYEENEMNGTYDYSQYELIC, of human CCR11

Supplied as a liquid in PBS, pH 7.2, 1mg/ml BSA, 0.09% sodium azide

Purified by affinity chromatography

Recognizes human CCR11. Peptide sequence is < 50% identical to other human chemokine receptors in this region. Species Crossreactivity: mouse