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You are here:Home » Antibodies » Abs to G Proteins » Anti -CCR11 (Chemokine Receptor 11, CKRB)

Anti -CCR11 (Chemokine Receptor 11, CKRB)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E B IH
Chemokine receptors are specialized proteins that function at the surface of cells, and enable chemokines to trigger internal cellular processes. Chemokines and their receptors play a pivotal role in lymphocyte trafficking, recruiting and recirculation. Chemokines act through seven transmembrane G protein-coupled receptors. The chemokine system is increasingly recognized to play an important role in lymphocyte biology.
Catalog #C2100-20
CCR11 is a G protein-coupled, seven-transmembrane receptor protein that plays a role in the chemotaxis and trafficking of leukocytes. Showing similar binding affinities as does CCR2 and CCR10 (1,2), CCR11 has been shown to specifically bind the MCP- (monocyte chemoattractant protein) family of chemokines, including MCP-4, MCP-2, and MCP-1. It was also shown to bind eotaxin (3). Though CCR11 shares functional similarity to CCR2 because it recognizes members of the MCP family, CCR11 has a distinct expression pattern (3).
Application(s)ELISA: 1:75,000
Western Blotting: 1:1,000
Immunohistochemistry: 1:250
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostGoat
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.2, 1mg/ml BSA, 0.1% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide EQNQSTDYYYEENEMNGTYDYSQYELIC corresponding to a 4-31 of human CCR11.
SpecificityPeptide sequence is < 50% identical to other human chemokine receptors in this region. Will cross-react to mouse CCR11. Crossreacts with human and mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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