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You are here:Home » Growth Factors, Cytokines » Growth Factors-CXCR » CCR8, Blocking Peptide (TER1, CKR-L1, ChemR1, Chemokine Receptor 8, CC-CKR-8)

CCR8, Blocking Peptide (TER1, CKR-L1, ChemR1, Chemokine Receptor 8, CC-CKR-8)

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Specifications

Peptide corresponding to amino acids 183 to 201 of human CCR8, which locate in the second extracellular loop (1-3).
CCR8 is one of the chemokine receptors that are required as coreceptors for HIV infection. The genes encoding human and murine CCR8 were cloned and designated TER1, CKR-L1, and ChemR1 (1-4). The encoded seven transmembrane protein was identified as the receptor for human CC chemokine I-309 and renamed CCR8. Recently, CCR8 was found to serve as a coreceptor for diverse T-cell tropic, dual-tropic and macrophage-tropic HIV-1 strains (5). CCR8 mediates CC chemokine I-309 induced monocyte chemoattraction and HIV-1 envelope fusion and virus infection, which can be prevented by the CCR8 ligand I-309. CCR8 is expressed in spleen, thymus and T lymphoblastic cell lines.
Catalog #C2100P
ApplicationsSuitable for use in blocking the activity of anti-CCR8 (Catalog #C2100).
Recommended DilutionBlocking: Incubating the pepetide with equal volume of antibody for 30 minutes at 37°C usuallly completely blocks the antibody activity in Western Blot. Optimal dilution determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
SourceSynthetic peptide
PurityPurified 60-70%
Concentration0.2mg/ml
FormSupplied as a liquid in PBS, pH .2, 0.1% BSA, and0.02% sodium azide.
Important NoteThis product is intended for research use only, not for use in human, therapeutic or diagnostic applications.


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