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You are here:Home » Antibodies » Abs to Cancer Markers » Anti -CCM2 (Malcavernin, Cerebral Cavernous Malformations 2 Protein, C7orf22, PP10187)

Anti -CCM2 (Malcavernin, Cerebral Cavernous Malformations 2 Protein, C7orf22, PP10187)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E B
CCM2 is a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells.
Catalog #C2105-01B
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:128,000
Western Blot: 0.03-0.1ug/ml, observed in human heart lysates on ~48kD bands
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to C-KGEKSRDKKAHEK, from human CCM2, at the internal region of the protein (NP_001025006.1, NP_113631.1, NP_001161407.1).
SpecificityRecognizes human CCM2. Species sequence homology: Bovine, canine, mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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