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You are here:Home » Antibodies » Abs to CD Markers » Anti -CD10 (CALLA, Common Acute Lymphocytic Leukemia Antigen, Neprilysin, NEP, Neutral Endopeptidase 24.11, EC3.4.24.11) (PE)

Anti -CD10 (CALLA, Common Acute Lymphocytic Leukemia Antigen, Neprilysin, NEP, Neutral
Endopeptidase 24.11, EC3.4.24.11) (PE)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified FC IF
CD10 (CALLA, Common Acute Lymphocytic Leukemia Antigen, Neprilysin, NEP, Neutral Endopeptidase 24.11, EC3.4.24.11) is a single chain 100kD glycoprotein, also known as Common Acute Lymphocytic Leukemia Antigen (CALLA), is a cell surface enzyme with neutral metalloendopeptidase activity which inactivates a variety of biologically active peptides. CD10 is expressed on the cells of lymphoblastic, Burkitt’s, and follicular germinal center lymphomas, and on cells from patients with chronic myelocytic leukemia (CML). It is also expressed on the surface of normal early lymphoid progenitor cells, immature B cells within adult bone marrow and germinal center B cells within lymphoid tissue. CD10 is also present on breast myoepithelial cells, bile canaliculi, fibroblasts, with especially high expression on the brush border of kidney and gut epithelial cells.
Catalog #C2261-41P
Antigen distribution Granulocytes > 95% cALL > 95% Peripheral blood lymphocytes < 1% T cells (lg+) < 1% B cells (lg-) < 1% Monocytes < 1% Thymocytes < 1% NK cells (CD16+) < 1%
ApplicationsSuitable for use in direct Immunofluorescence for Flow Cytometric analysis. Other applications not tested.
Recommended DilutionFlow Cytometry: 20ul/1x10e6 cells or 100ul peripheral blood cells.
Optimal dilution determined by the researcher.
Storage and StabilityMay be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No5F12
HostMouse
SourceHuman
Concentration40ul/test
FormSupplied as a liquid in PBS, pH 7.2, 0.1% BSA, 0.1% sodium azide before the addition of glycerol to 40%. Conjugated to PE.
PurityPurified by Protein G affinity chromatography.
SpecificityRecognizes neutral endopeptidase, a 100kD type II transmembrane glycoprotein, which is refered as the Common Acute Lymphoblastic Leukemia Antigen (CALLA). Reacts with normal human peripheral blood granulocytes (99%) and REH cell (94%), is negative in peripheral blood lymphocytes and monocytes.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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