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Anti -CD11b (Mac-1, alphaM integrin, Cr3, MO-1, C3bi Receptor) (FITC)
Anti -CD11b (Mac-1, alphaM integrin, Cr3, MO-1, C3bi Receptor) (FITC)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Rat |
Highly Purified |
IC |
|
| Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Integrin alpha-m/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. CD-11b is identical with cr-3, the receptor for the ic3b fragment of the third complement component. CD-11b probably recognizes the r-g-d peptide in c3b. Integrin alpha-m/beta-2 is also a receptor for fibrinogen, factor x and icam1. it recognizes p1 and p2 peptides of fibrinogen gamma chain. | | | Catalog # | C2262-34U | | Applications | Suitable for use in Immunocytochemistry. Other applications have not been tested. | | Recommended Dilutions | | | Immunocytochemistry: Use 10ul/10e6 cells. | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | Lyophilized powder may be stored at 4°C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol, ddH2O. Aliquot and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer. FITC conjugates are sensitive to light. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG2b | | Clone No | 5C29 | | Host | Rat | | Source | Mouse | | Concentration | ~1mg/ml | | Form | Supplied as a lyophilized powder in PBS, pH 7.2. Labeled with FITC. Reconstitute with 500ul of sterile 40-50% glycerol , dH2O. | | Purity | Purified by ion exchange chromatography. | | Immunogen | Purified mouse LN CD4+ T cells. | | Specificity | Recognizes mouse CD11b and will block signal through the CD11a molecule. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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