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You are here:Home » Antibodies » Abs to Integrin » Anti -CD11b (Mac-1, alphaM integrin, Cr3, MO-1, C3bi Receptor) (FITC)

Anti -CD11b (Mac-1, alphaM integrin, Cr3, MO-1, C3bi Receptor) (FITC)

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Specifications

Clone Host Grade Applications
Monoclonal Rat Highly Purified IC
Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Integrin alpha-m/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. CD-11b is identical with cr-3, the receptor for the ic3b fragment of the third complement component. CD-11b probably recognizes the r-g-d peptide in c3b. Integrin alpha-m/beta-2 is also a receptor for fibrinogen, factor x and icam1. it recognizes p1 and p2 peptides of fibrinogen gamma chain.
Catalog #C2262-34U
ApplicationsSuitable for use in Immunocytochemistry. Other applications have not been tested.
Recommended Dilutions
Immunocytochemistry: Use 10ul/10e6 cells.
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at 4°C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol, ddH2O. Aliquot and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer. FITC conjugates are sensitive to light.
Clone TypeMonoclonal
IsotypeIgG2b
Clone No5C29
HostRat
SourceMouse
Concentration~1mg/ml
FormSupplied as a lyophilized powder in PBS, pH 7.2. Labeled with FITC. Reconstitute with 500ul of sterile 40-50% glycerol , dH2O.
PurityPurified by ion exchange chromatography.
ImmunogenPurified mouse LN CD4+ T cells.
SpecificityRecognizes mouse CD11b and will block signal through the CD11a molecule.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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