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Anti -Integrin alpha 1 (CD49a, VLA-1, CD49a, Laminin and Collagen Receptor)
Anti -Integrin alpha 1 (CD49a, VLA-1, CD49a, Laminin and Collagen Receptor)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Sheep |
Affinity Purified |
E B |
|
| Integrin alpha 1 (also VLA-1, CD49a and Laminin and Collagen Receptor) is a 190-210kD member of the integrin alpha chain family of molecules. It is found on smooth muscle cells, osteoblasts, adipocytes and intestinal epithelium. Integrin alpha 1 forms a noncovalent heterodimer with Integrin beta 1, and serves as a divalent-cation dependent receptor for collagen types I, IV, VI, XIII and XVI. It also binds the diarrhea-associated NSP4 enterotoxin of rotavirus. Mature human Integrin alpha 1 is a 1151 aa type I transmembrane glycoprotein that contains a 1113aa extracellular domain (ECD) and a 15aa cytoplasmic tail. The ECD contains one vWFA/I-domain (aa147-360) that binds collagen, plus multiple divalent cation binding sites. Potential splice variants exist that show a two and four aa substitution for aa 765-1179. Over aa29-1141 (the ECD), human Integrin alpha 1 shares 88% aa identity with mouse | | | Integrin alpha 1. | | | | | | Applications: | | | Suitable for use in ELISA and Western Blot. Other applications not tested. | | | Catalog # | C2262-36J | | Recommended Dilution | ELISA: 0.5-1.0ug/ml | | Western Blot: 1.0ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile 40-50% glycerol, PBS.. Aliquot and store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Sheep | | Source | Human | | Concentration | ~0.2mg/ml | | Form | Supplied as a lyophilized powder in 0.2um sterile-filtered solution, PBS, 5% trehalose. Reconstitute with 40-50% glycerol, PBS. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | CHO cell-derived, recombinant human Integrin alpha 1 extracellular domain aa29-1141; P56199. | | Specificity | Recognizes human Integrin alpha 1 extracellular domain. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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