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You are here:Home » Antibodies » Abs to Integrin » Anti -CD11b/c (CD11 Antigen-like Family Member C, CD11b, CD11b Antigen, CD11c, Cell Surface Glycoprotein MAC-1 alpha Subunit, Complement Component Receptor 3 alpha, CR3 alpha Chain, CR-3 alpha Chain, CR3A, Integrin alpha M Complement Component 3 Receptor 3 Subu

Anti -CD11b/c (CD11 Antigen-like Family Member C, CD11b, CD11b Antigen, CD11c, Cell
Surface Glycoprotein MAC-1 alpha Subunit, Complement Component Receptor 3 alpha, CR3 alpha
Chain, CR-3 alpha Chain, CR3A, Integrin alpha M Complement Component 3 Receptor 3 Subu

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
CD11b is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement coated particles. It is identical to CR3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the RGD peptide in C3b. CD11b is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. The Mac1 CD11b antigen is present on macrophages, granulocytes, natural killer cells, blood monocytes. CD11b is expressed on 8% spleen cells, 44% bone marrow cells and less than 1% of thymocytes and is commonly used as a microglial marker in nervous tissue.
Catalog #C2262-53C
ApplicationsSuitable for use in Western Blot, Immunohistochemistry. Other applications not tested.
Recommended DilutionsWestern Blot: 2ug/ml
Immunohistochemisty (regular/paraffin): 5-10ug/ml
Optimal dilutions to be determined by researcher.
Positive ControlRAW 264.7 cell lysate
Storage and StabilityStore at 2-8°C. Do Not Freeze! Aliquots are stable for at least 3 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates.
Clone TypePolyclonal
HostRabbit
SourceMouse
Concentration1.2mg/ml
FormSupplied as a liquid in Tris-glycine, 150mM sodium chloride. Labeled with HRP.
PurityPurified by immunoaffinity chromatography.
ImmunogenA synthetic peptide made to an internal region (aa500-600) of the mouse CD11 (b/c) protein.
SpecificityRecognizes CD11b/c. Using macrophage lysates, a doublet is seen ~95 and 103kD. A weaker doublet is also seen ~130 and 160kD. Species Crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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