| CD11b is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement coated particles. It is identical to CR3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the RGD peptide in C3b. CD11b is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. The Mac1 CD11b antigen is present on macrophages, granulocytes, natural killer cells, blood monocytes. CD11b is expressed on 8% spleen cells, 44% bone marrow cells and less than 1% of thymocytes and is commonly used as a microglial marker in nervous tissue. |
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| Catalog # | C2262-55E |
| Applications | Suitable for use in Flow Cytometry, Immunoprecipitation and Immunohistochemistry. Other applications not tested. |
| Recommended Dilutions | Immunohistochemistry: Frozen |
| Optimal dilutions to be determined by the researcher. |
| Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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| CAS Number | n/a |
| Clone Type | Monoclonal |
| Isotype | IgG1 |
| Clone No | 8J588 |
| Host | Mouse |
| Source | Human |
| Concentration | ~1mg/ml |
| Form | Supplied as a liquid in PBS, pH 7.4, 1mg/ml BSA. |
| Purity | Purified by Protein A affinity chromatography. |
| Immunogen | Tissue / cell preparation (Human). Synovial cells and human monocytes. Cellular Localization: Type I membrane protein. |
| Specificity | Recognizes the X chain of the human CD11c/CD18 (p150/95) integrin heterodimer. Species Crossreactivity: Rhesus monkey. |
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| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
| Alternate names | Complement component 3 receptor 4 subunit, ITGAX, LEU M5 alpha subunit, Leukocyte adhesion glycoprotein p150 95 alpha chain, Leukocyte adhesion receptor p150 95, Leukocyte surface antigen p150 alpha subunit, Myeloid membrane antigen alpha subunit, p150 95 |
