Anti -CD21 (CR2, C3d Receptor, EBV Receptor)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Purified |
E |
|
| CD21 is also known as CR2, C3d receptor and EBV receptor. Its epitope maps within 5-8 short consensus repeats (SCRs) of CD21 molecule. CD21 is expressed strongly on mature B cells, follicular dentritic cells, pharyngeal, cervical epithelial cells and weakly on immature thymocytes and T lymphocytes. In B-cell ontogeny, CD21 appears after the pre-B-stage, is maintained during peripheral B-cell development and is lost upon terminal differentiation into plasma cells. CD21 expression is also gradually lost after stimulation of B cells in vitro. CD21 functions as receptor for C3d, C3dg and iC3b Complement components, for EBV and for IFNa. CD21 is also known as Complement Receptor Type 2 (CR2) or Epstein-Barr virus (EBV) receptor. CD21 binds to CD23 and associates with CD19, CD81 and Leu13 to form a large signal-transduction complex involved in B cell activation. | | | Catalog # | C2272-61 | | Applications | Suitable for use in ELISA. Other applications not tested. | | Recommended Dilutions | ELISA: 1:1000. | | Optimal dilutions to be determined by the researcher. | | Hybridoma | X63.653 myeloma cells with spleen cells from Balb/c mice. | | Storage and Stability | | | May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 1.BB.275 | | Host | Mouse | | Source | Human | | Concentration | ~5.0mg/ml | | Form | Supplied as a liquid in PBS, pH 7.2, 0.1% sodium azide . | | Purity | Purified by Protein G chromatography. | | Immunogen | Normal human lymphocytes from lymph node. Molecular Weight: 140kD. | | Specificity | Recognizes human CD21. The CD21 molecule is the receptor for C3d and also for EBV. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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