Anti -CD21 (CR2, C3d Receptor, EBV Receptor)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Supernatant |
IH |
|
| CD21 is also known as CR2, C3d receptor and EBV receptor. Its epitope maps within 5-8 short consensus repeats (SCRs) of CD21 molecule. CD21 is expressed strongly on mature B cells, follicular dentritic cells, pharyngeal, cervical epithelial cells and weakly on immature thymocytes and T lymphocytes. In B-cell ontogeny, CD21 appears after the pre-B-stage, is maintained during peripheral B-cell development and is lost upon terminal differentiation into plasma cells. CD21 expression is also gradually lost after stimulation of B cells in vitro. CD21 functions as receptor for C3d, C3dg and iC3b Complement components, for EBV and for IFNa. CD21 is also known as Complement Receptor Type 2 (CR2) or Epstein-Barr virus (EBV) receptor. CD21 binds to CD23 and associates with CD19, CD81 and Leu13 to form a large signal-transduction complex involved in B cell activation. | | | Catalog # | C2272-66 | | Applications | Immunohistochemistry (frozen & formalin/paraffin). Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10-20 min., followed by cooling at RT for 20 min. | | Recommended Dilution: 1:10 to 1:20 | | Optimal dilutions to be determined by the researcher. | | Clone Type | Monoclonal | | Isotype | IgG2a | | Clone No | 0.N.89 | | Host | Mouse | | Source | Human | | Concentration | As reported | | Form | Supplied as concentrated tissue culture supernatant in 15mM sodium azide. | | Purity | Tissue culture supernatant | | Immunogen | Recombinant protein encoding the external domain of human CD21. | | Specificity | Recognizes CD21 at 140kDa. Species Reactivity: Human. | | | Important Note | This product is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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