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Anti -CD47 (Leukocyte Surface Antigen CD47, Antigenic Surface Determinant Protein OA3, Integrin-associated Protein, IAP, Protein MER6, MER6) (Azide Free)
Anti -CD47 (Leukocyte Surface Antigen CD47, Antigenic Surface Determinant Protein OA3,
Integrin-associated Protein, IAP, Protein MER6, MER6) (Azide Free)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
B IP FC N |
|
| CD47, originally named integrin-associated protein (IAP), is a 50kD protein containing five membrane spanning sequences and a short cytoplasmic tail. CD47 appears to be important in myeloid cell activation and migration across endothelial and epithelial monolayers. Anti-CD47 antibody has been shown to inhibit polymorphonuclear neutrophil (PMN) transmigration across cell monolayers and matrix. CD47 and its ligands, thrombospondin 1 (TSP-1) and SIRP-a, are important regulators of dendritic cells. Recently, it has been shown that CD47 and TLR2 cross-talk to regulate PMN transmigration. The activation of TLR2/6 by MALP-2, a TLR2 specific agonist, potently inhibits human and murine PMN transmigration. The cross-talk between TLR2 and CD47 may be mediated through MYD88. | | | Catalog # | C2402-02C | | Applications | Suitable for use in Western Blot, Immunoprecipitation, Neutralization and Flow Cytometry. Other applications not tested. | | Recommended Dilution | Flow Cytometry: 0.5-1ug/10e6 cells | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 11E100 | | Host | Mouse | | Source | Human | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in PBS. Preservative free. | | Purity | Purified by Protein G affinity chromatography. | | Immunogen | Human CD47. | | Specificity | Recognizes human CD47. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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