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You are here:Home » Antibodies » Abs to CD Markers » Anti -CD49e (Integrin alpha5) (FITC)

Anti -CD49e (Integrin alpha5) (FITC)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Purified IH FC
CD49e is the integrin alpha5 chain, a 135/25kD heterodimer, that associates noncovalently with CD29, the integrin beta1 subunit, to form the alpha5beta1 very late antigen-5 (VLA-5) complex, a very well established fibronectin receptor that is expressed on many cell types, including thymocytes, T cells, monocytes and platelets. Expression of the VLA-5 heterodimer is increased on activated and memory T cells. It is also found on very early B cells and on activated B lymphocytes. CD49e/CD2-mediated binding to fibronectin provides a costimulatory signal to T cells. It also enhances Fc-gammaR- and complement receptor-mediated phagocytosis, and is involved in monocyte migration into extracellular tissues.1-6
Catalog #C2405-01V
ApplicationsSuitable for use in Flow Cytometry, Immunohistochemistry and Function blocking. Other applications not tested.
Recommended DilutionFlow Cytometry: 20ul/10e6 cells
Immunohistochemistry: Frozen
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. FITC conjugates are sensitive to light.
Clone TypeMonoclonal
IsotypeIgG2b
Clone No5K288
HostMouse
SourceHuman
Concentration~100tests/ml
FormSupplied as a liquid in PBS, 0.1% sodium azide and a stabilizing agent. Labeled with FITC.
PurityPurified
ImmunogenHuman CD49e.
SpecificityRecognizes human CD49e.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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