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You are here:Home » Antibodies » Abs to Integrin » Anti -CD49f (Laminin Receptor, Integrin alpha6, VLA alpha6, Platelet gpIc)

Anti -CD49f (Laminin Receptor, Integrin alpha6, VLA alpha6, Platelet gpIc)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified IP IH FC
Integrins are a family of dimeric, transmembrane proteins that mediate cell-cell and extracellular matrix adhesion. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis. The integrin family is composed of at least 15 alpha and 8 beta subunits that may form over twenty different alpha-beta non-covalently bound dimeric combinations on the cell surface. The alpha subunits all have some homology to each other, as do the beta subunits. Both of the subunits contribute to the binding of the ligand. Integrin alpha subunits contain seven weak sequence repeats in the N-terminal region, which may be important in ligand binding, and have been predicted to fold cooperatively into a single beta-propeller domain with seven beta-sheets. In normal tissue, Integrin alpha-6/beta-1 is a receptor for laminin on human platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome. Various disease states involving epithelial cells have been shown to be associated with alterations in alpha 6 integrin-containing heterodimers.
Catalog #C2405-03
ApplicationsSuitable for use in Flow Cytometry, Immunohistochemistry, Immunoprecipitation and Inhibition. Other applications have not been tested.
Recommended DilutionsFlow Cytometry: 1:25-1:50; Use 10ul per 10e6 cells in 100ul.
Immunohistochemistry: Frozen tissue sections
Inhibition of laminin binding: 40ug/ml.
Optimal dilutions to be determined by researcher.
Positive ControlHuman tonsil (for Immunohistochemistry)
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
Clone TypeMonoclonal
IsotypeIgG2a
Clone No2Q957
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenBALB/c mouse mammary tumor cells.
SpecificityRecognizes human Cdw49f-antigen, 120kD, (GP Ic or VLA-6 alpha-chain). Inhibits platelet adhesion to laminin. Reacts with platelets, megakaryocytes, T lymphocytes and common Acute Lymphoblastic Leukemia cells (alpha-6 beta-1). Reacts with epithelial cells of a variety of tissues, peripheral nerves, microvascular endothelial cells, placenta cyto- and syncytotrophoblasts. Species Crosseactivity: Mouse, Cynomologus monkey, porcine, and canine.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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