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You are here:Home » Antibodies » Abs to CD Markers » Anti -CD54 (Intercellular Adhesion Molecule, ICAM-1) (Biotin)

Anti -CD54 (Intercellular Adhesion Molecule, ICAM-1) (Biotin)

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Specifications

Clone Host Grade Applications
Monoclonal Rat Purified B IP IH FC
CD54, a member of the immunoglobulin superfamily of cell surface receptors and also known as Intercellular Adhesion Molecule-1 (ICAM-1), is a type I transmembrane glycoprotein that mediates important cell/cell interactions. CD54 is expressed on endothelial cells, dendritic cells, keratinocytes and lymphocytes. Its expression is upregulated by inflammatory mediators such as IFN-gamma, IL-1, TNF-alpha, lipopolysaccharide and phorbol esters. Endothelial CD54 contributes to the extravasation of leukocytes from blood vessels, particularly in areas of inflammation. CD54 on antigen-presenting cells contributes to antigen-specific T-cell activation, presumably by enhancing interactions between T cell and antigen-presenting cells. These adhesion reactions are mediated via the binding of CD54 to its major ligands, LFA-1 and Mac-1.
Catalog #C2409-19J
ApplicationsSuitable for use in Western Blot, Immunoprecipitation, Flow Cytometry, Immunohistochemistry, and in vitro blocking studies. Other applications have not been tested.
Recommended DilutionFlow Cytometry: 1ug/10e6 cells
Immunohistochemistry: Frozen sections.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2b,k
Clone No5K16
HostRat
SourceMouse
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.1% sodium azide. Labeled with Biotin.
PurityPurified
ImmunogenMouse CD54
SpecificityRecognizes mouse CD54/ICAM-1, Mr 95kD.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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