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You are here:Home » Antibodies » Abs to CD Markers » Anti -CD56 (NCAM-1, Neural Cell Adhesion Molecule)

Anti -CD56 (NCAM-1, Neural Cell Adhesion Molecule)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B IH IF
The Immunoglobulin superfamily of cell adhesion molecules is related to the immunoglobulins proteins by structure. The family contains over a 100 members that include ICAM (intercellular adhesion molecule), NCAM (neural cell adhesion molecule) and NgCAM (neural-glial cell adhesion molecule). Both NCAM and NgCAM are calcium independent adhesion molecules. NCAM, the first CAM to be characterized, is expressed on all neurons from very early in development. It binds homophilically to NCAM on adjacent cells and has a variety of functions during neural development. One of these important functions is to hold developing neurites together during neuron outgrowth and formation of neural connections. The adhesive properties of NCAM are modulated during development and plasticity by the presence of the regulated carbohydrate, polysialic acid (PSA). The post-translational addition of alpha-2,8-linked PSA (NCAM-PSA) appears to contribute to synaptic plasticity during learning and memory formation and to the mechanisms of nerve regeneration.
Catalog #C2410-69A
ApplicationsSuitable for use in Western Blot, Immunofluorescence, Immunohistochemistry, ELISA and Functional Blocking. Other applications have not been tested.
Recommended DilutionsWestern Blot (ECL): 1:1000 on 10ug of mouse brain lysate.
Immunohistochemistry (Wide range of fixatives): 1ug/ml will detect chicken NCAM; 2ug/ml will detect mouse NCAM.
ELISA: 0.3ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlNeuraminidase-treated mouse brain membrane
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceChicken
Concentration~1mg/ml
FormSupplied as a liquid in PBS. No preservatives added.
PurityPurified by immunoaffinity chromatography.
ImmunogenHighly purified chicken NCAM. Molecular Weight: 200-250kD; When treated with Neuraminidase, 140-180kD. A breakdown product of 160kD may also be visible.
SpecificityRecognizes chicken Neural Cell Adhesion Molecule (NCAM). Species Crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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