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You are here:Home » Antibodies » Abs to Integrin » Anti -CD61 (ITGB3, Integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61), GP3A, GPIIIa, Integrin beta-3, Platelet membrane glycoprotein IIIa)

Anti -CD61 (ITGB3, Integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61), GP3A,
GPIIIa, Integrin beta-3, Platelet membrane glycoprotein IIIa)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified IP IC FC
The antibody can be used to immunoprecipate a complex of CD41 and CD61. The apparent molecular weight of the GPIIIa by SDS-PAGE in immunoprecipitaton is 105kD reduced and 90kD unreduced (prelabelled surface proteins). Ligands are fibronectin, fibrinogen, von Willebrand factor, vitronectin and thrombospondin. Residues 237-248 of GPIIIa or CD61 are critical in adhesive protein binding. The CD41/CD61 complex is also found on endothelial cells, some B cells, monocytes/macrophages and tumor cells. The monocytoid cell line U937 is highly positive.
Catalog #C2414-17
ApplicationsImmunoprecipitation
Immunocytochemistry (acetone fixation required)
Flow cytometry
Inhibits platelet aggregation, 10ug/ml
Storage and Handling Maintain between 2 and 8°C, for 12 months
Clone TypeMonoclonal
IsotypeIgM
Clone No2Q800
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in buffer of 0.02M phosphate, 0.25M sodium chloride, pH 7.6, 0.1% sodium azide
PurityPurified from ascites by protein A chromatography
ImmunogenNormal blood mononuclear cells activated by mixed lymphocyte reaction and cultured for 10 days in medium containing IL-2.
SpecificityReacts with human integrin beta 3 (GPIIIa, vitronectin receptor beta chain).
Important NoteThis product is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Alternate namesPlatelet glycoprotein IIIa, ITGB3, GP3A


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