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You are here:Home » Antibodies » Abs to CD Markers » Anti -CD100, aa777-788 (Leukocyte Semaphorin)

Anti -CD100, aa777-788 (Leukocyte Semaphorin)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
CD100, also known as leukocyte semaphorin), is a homodimeric protein expressed on majority of hemopoietic cells (B, T, NK and myeloid cells) and is absent from bone marrow, erythrocytes, eosinophils and endothelial cells. CD100 was shown to associate with different partner molecules in T cells such as CD45, a key molecule with protein tyrosine phosphatase activity involved in T-cell transduction, and serin kinase. It plays a role in homotypic cell adhesion and in T cell activation. It expression is increased after PHA-activation.
Catalog #C2445-12
Semaphorins are neuronal chemo-repellants that direct pioneering neurons during nervous system development. CD100 is a novel semaphorin that induces B cells to aggregate and improves their viability in vitro. CD100 modi es CD40-CD40L B-cell signaling by augmenting B-cell aggregation and survival and down-regulating CD23 expression. CD72 is a lymphocyte receptor for the Class IV semaphorin CD100, which is involved in regulating B cell signaling.
ApplicationsSuitable for use in Western Blot. Other applications have not been tested.
Recommended DilutionWestern Blot: 1:250-1:500
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 0.01% sodium azide before the addition of 40% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide, aa777-788 [KPKSDFCDREQS] of the human CD100 protein.
SpecificityReacts with residues 777788 [KPKSDFCDREQS] of the human CD100 protein.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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