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You are here:Home » Antibodies » Abs to Integrin » Anti -CD103 (Integrin alpha E, Integrin alpha M290, Itgae, Integrin alpha E, Epithelial-associated, A530055J10, alpha-E1, alpha-M290, aM290, MGC183601)

Anti -CD103 (Integrin alpha E, Integrin alpha M290, Itgae, Integrin alpha E,
Epithelial-associated, A530055J10, alpha-E1, alpha-M290, aM290, MGC183601)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Hamster Affinity Purified IP IH FC
CD103 is a type I transmembrane glycoprotein known as aE integrin or Integrin aIEL chain. It belongs to integrin family and is primarily found on intestinal intraepithelial lymphocytes (IEL). CD103 is also expressed on a subpopulation of lamina propria T cells, epithelial dendritic cells, lamina propria-derived dendritic cells, and a small subset of peripheral lymphocytes. T regulatory cells express high level of CD103. The CD103 expression on lymphocytes can be induced upon activation and TGF-b stimulation. In association with integrin b7, CD103 is expressed as aE/b7 heterodimer. Mature CD103 protein can be cleaved into 2 chains, a 150kD (C-terminal) chain and a 25kD (N-terminal) chain, which remain linked by disulfide bonds. CD103 binds to E-cadherin and mediates homing of lymphocytes to the intestinal epithelium.
Catalog #C2445-63R
ApplicationsSuitable for use in Flow Cytometry, Immunohistochemistry and Immunoprecipitation. Other applications not tested.
Recommended DilutionFlow Cytometry: 1ug/10e6 cells in 100ul volume
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG
HostHamster
SourceMouse
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenMouse intestinal intraepithelial lymphocytes
SpecificityRecognizes mouse CD103.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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