Anti -CD103 (Integrin alpha E, Integrin alpha M290, Itgae, Integrin alpha E,
Epithelial-associated, A530055J10, alpha-E1, alpha-M290, aM290, MGC183601)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Hamster |
Affinity Purified |
IP IH FC |
|
| CD103 is a type I transmembrane glycoprotein known as aE integrin or Integrin aIEL chain. It belongs to integrin family and is primarily found on intestinal intraepithelial lymphocytes (IEL). CD103 is also expressed on a subpopulation of lamina propria T cells, epithelial dendritic cells, lamina propria-derived dendritic cells, and a small subset of peripheral lymphocytes. T regulatory cells express high level of CD103. The CD103 expression on lymphocytes can be induced upon activation and TGF-b stimulation. In association with integrin b7, CD103 is expressed as aE/b7 heterodimer. Mature CD103 protein can be cleaved into 2 chains, a 150kD (C-terminal) chain and a 25kD (N-terminal) chain, which remain linked by disulfide bonds. CD103 binds to E-cadherin and mediates homing of lymphocytes to the intestinal epithelium. | | | Catalog # | C2445-63R | | Applications | Suitable for use in Flow Cytometry, Immunohistochemistry and Immunoprecipitation. Other applications not tested. | | Recommended Dilution | Flow Cytometry: 1ug/10e6 cells in 100ul volume | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG | | Host | Hamster | | Source | Mouse | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Mouse intestinal intraepithelial lymphocytes | | Specificity | Recognizes mouse CD103. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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