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You are here:Home » Antibodies » Abs to CD Markers » Anti -CD103 (CD103 Antigen, HML-1 Antigen, Human Mucosal Lymphocyte Antigen 1, Huminae, Integrin alpha E, ITGAE, Integrin alpha IEL, MGC141996, Mucosal Lymphocyte 1 Antigen, Mucosal Lymphocyte Antigen 1)

Anti -CD103 (CD103 Antigen, HML-1 Antigen, Human Mucosal Lymphocyte Antigen 1, Huminae,
Integrin alpha E, ITGAE, Integrin alpha IEL, MGC141996, Mucosal Lymphocyte 1 Antigen,
Mucosal Lymphocyte Antigen 1)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Hamster Purified IP IH FC
CD103 is a member of the integrin series of adhesion molecules. This antigen defines a developmentally important subset of T cells, namely mucosal T cells including all IEL (intraepithelial lymphocytes) and ~20% of lamina propria T cells. Expression of CD103 is more restricted outside these mucosal organs, appearing at lower levels on T cell subsets of the lymph node, dendritic epidermis and periphery.1-3 In non-epithelial CD103+ T cells there is a bias toward expression on CD8+ cells. This antibody is reported to have signal-inducing activity in a redirected lysis assay and to co-stimulate IEL and CD8+ lymph node cells in conjunction with anti-TCR in vitro, which runs counter to the usual inhibition of CTL by anti-integrins.1 The property of costimulation is not unique to the mouse since the combination of anti-human alphaIEL plus anti-TCR will produce similar proliferation in human cells, with the exception that CD8+ cells are not stimulated.5
Catalog #C2445-65C
ApplicationsSuitable for use in Flow Cytometry, Immunohistochemistry, Immunoprecipitation and In vitro activation. Other applications have not been tested.
Recommended DilutionImmunohistochemistry: Frozen sections
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG
Clone No2E7
HostHamster
SourceMouse
Concentration~0.5mg/ml
FormSupplied as a liquid in 100mM BBS, pH 8.0. No preservatives or amine-containing buffer salts added.
PurityPurified
ImmunogenMouse intestinal intraepithelial lymphocytes
SpecificityRecognizes mouse CD103 (aIELb7 integrin complex) at160 and 115kD.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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