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You are here:Home » Antibodies » Abs to CD Markers » Anti -CD105 (Endoglin, gp160, TGF beta1,3 Receptor)

Anti -CD105 (Endoglin, gp160, TGF beta1,3 Receptor)

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Specifications

Clone Host Grade Applications
Monoclonal Rat Purified B IH FC
CD105 (Endoglin, gp160, TGF beta1,3 Receptor) is a disulfide-linked type II transmembrane homodimer that is predominantly expressed on vascular endothelial cells. It is also found on pre-erythroblasts, macrophages and lymphoid and myeloid leukemic cells. Both mouse and human CD105 exhibit > 70% sequence homology in their cytoplasmic domains with type III transforming growth factor beta (TGFb) receptor. CD105 has been shown to be one of several receptors for the various isoforms of TGFb, which in turn is one of a family of proteins involved in regulation of cell differentiation, migration of cells and control of the immune response.
Catalog #C2446-50C
ApplicationsSuitable for use in Identification and enumeration of CD105 + cells by Flow Cytometry, Immunohistochemistry and Western Blot. Other applications not tested.
Recommended DilutionFlow Cytometry: 1ug/10e6 cells
Immunohistochemistry: Frozen sections
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG2a,k
Clone No5K262
HostRat
SourceMouse
Concentration~0.5mg/ml
FormSupplied as a liquid in 100mM borate buffered saline, pH 8.0. No preservatives or amine-containing buffer salts added.
PurityPurified
ImmunogenInflamed mouse skin.
SpecificityRecognizes mouse endoglin, Mr 90kD.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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