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You are here:Home » Antibodies » Abs to Disease Markers » Anti -CD105 (Endoglin, gp160, TGF beta1,3 Receptor, HHT1, ORW1, Osler Rendu Weber syndrome 1)

Anti -CD105 (Endoglin, gp160, TGF beta1,3 Receptor, HHT1, ORW1, Osler Rendu Weber syndrome
1)

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Specifications

Clone Host Grade Applications
Monoclonal Rabbit Purified B
Endoglin (ENG, CD105) is an auxiliary receptor for the TGF-Beta receptor complex, functioning in related signaling pathways (1,2). Endoglin is a transmem-brane protein that exists as a disulfide-linked homodimer. It is mainly expressed in vascular and connective tissues and in endothelial and stromal cells. Upregulated endoglin expression has been reported during wound healing and tumor vascularization, and in inflammatory tissues and developing embryos (1-4). Mutations in endoglin have been found to be a causal factor of hereditary hemorrhagic tel-
angiectasia (HHT), a disease characterized by malformation of vascular structure (5,6). The importance of this protein for normal and tumor vascular function makes it a good marker for endothelial cell proliferation as well as a potential therapeutic target in cancer (4-6).
Catalog #C2446-50E5
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG
Clone No10E14
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied in 10mM sodium HEPES pH 7.5, 150mM NaCl, 100ug/ml BSA, 50% glycerol and less than 0.02% sodium azide.
PurityPurified
ImmunogenSynthetic peptide corresponding to residues surrounding Ala463 of
human endoglin protein (KLH).
SpecificityRecongnizes endogenous levels of human total endoglin protein.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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